Shaping tool having a rotatable base member

ABSTRACT

A shaping tool as depicted in exemplary FIG.  3  comprising a rotatable base member having at least one profiled bending roller ( 13 ) which is mounted on a circular track and is rotatable about a rotation axis. The bending roller ( 13 ) arranged on a radially movable slide ( 11 ) is movable from a position defining a maximum working aperture for the tool, by means of a spring-loaded lever ( 9 ) which has an axial configuration, into a position defining a minimum working aperture for the tool.

The invention relates to a shaping tool which comprises a rotatable basemember having at least one profiled bending roller which is mounted on acircular track and is rotatable about a rotation axis.

BACKGROUND OF THE INVENTION

For administering inhalable pharmaceutical formulations of activesubstances, the patient uses hand-held, manually operated inhalers inwhich the pharmaceutical active substance formulation is contained in aninhaler cartridge. The inhaler cartridge consists of an externalaluminium cartridge and a plastic container inserted therein, theplastic container being produced by co-extrusion and comprising a rigidouter container and a flexible inner pouch disposed inside it. In orderto create a pressure equalisation opening between the inner pouch andthe outer container, an opening is formed in the relatively rigid outercontainer by the so-called cut-crack-open process, for example. Theplastic container is filled with the pharmaceutical active substanceformulation and sealed, and inserted into the aluminium cartridge duringthe manufacturing process to form the inhaler cartridge. In a subsequentstep, a deformed wall region is formed in the aluminium cartridge in theupper region of the inhaler cartridge thus assembled, this deformedregion bearing on the outer surface of the plastic container inserted inthe aluminium cartridge. To form the attachment region on the upper edgeof the aluminium cartridge a drawing process is used in which a rotatingdrawing tool moves with its working aperture for the tool from aboveover the attachment region to be formed on the aluminium cartridge andthereby brings profiled drawing rollers arranged around the workingaperture for the tool into contact with the outer surface of thealuminium cartridge, in order to shape the attachment region by axialmovement. Then in another manufacturing step the aluminium cartridge isapplied in gastight manner against the outside of the plastic containerdisposed therein, which is filled with a pharmaceutical active substanceformulation.

In the case of a shaping tool known in the art, comprising a rotatablebase member with profiled bending rollers arranged on a circular trackand rotatable about a rotation axis, the bending rollers are moved in aradial pivoting movement in one plane from a maximum working aperturefor the tool into a minimum working aperture for the tool. This shapingtool has proved problematic in its reliability and susceptibility tobreakdown.

SUMMARY OF THE INVENTION

The problem that the invention sets out to solve is to provide a shapingtool of the kind mentioned hereinbefore which is reliable in operation.

According to the invention the problem is solved by the fact that thebending roller arranged on a radially movable slide is movable from aposition that defines a maximum working aperture for the tool, by meansof a spring-loaded lever with an axial configuration, into a positionthat defines a minimum working aperture for the tool.

Since the shaping tool rotates, the workpiece, i.e. the inhalercartridge which is to be produced, filled with a liquid active substanceformulation, can be fixed in place, thereby preventing foaming of theactive substance formulation. The shaping tool is positioned relative tothe workpiece, while the bending roller is located in the positiondefining the maximum working aperture for the tool. By an adjustingmovement using the lever, the bending roller is moved into the positiondefining the minimum working aperture for the tool. The profiled bendingroller is matched to the contour that is to be produced and as a resultof the radial adjustment an encircling radius, for example, is producedin rotationally symmetrical manner on an upper edge of the obviouslycylindrical workpiece, whereby after an initial adjustment ordetermination of the diameter of the minimum working aperture for thetool a reliable product which is accurate in its shape and dimensions isobtained. The resetting of the bending roller from the minimum workingaperture for the tool to the maximum working aperture for the tool iscarried out by means of a radially acting compression spring.

According to a further feature, in the center, an axially actingdepressor for the clamped workpiece is provided and a pressing memberthat is conical at least in parts is axially movable under springloading relative to the depressor, while the pressing member cooperateswith one end of the lever in order to move the bending roller into theminimum working aperture for the tool. When the rotating shaping toolmoves axially downwards, first of all the depressor makes contact withthe workpiece, which consists of an aluminium cartridge with a plasticcontainer inserted therein. The depressor presses the plastic containerinto the aluminium cartridge and holds the workpiece. Thus the depressorperforms the function of positioning the plastic container in thealuminium cartridge. At this height in which the depressor secures theworkpiece in the axial direction, the bending roller is also positionedat the required height. During further downward motion the pressingmember is moved downwards and the cone of the pressing member acts uponthe lever in order to shift the bending roller in the radial directioninto the position of the minimum working aperture for the tool where theworkpiece has its end contour. In the event of incorrect axialpositioning, the pressing member would act upon the lever too early ortoo late, resulting in a defective and in particular non-gastight endcontour.

In order to convert the axial movement of the pressing member into theradial direction of movement of the bending roller the lever ispreferably provided, at its end facing the pressing member, with aroller that rolls on the pressing member and at its opposite end it ispivotably connected to the slide.

So that the bending roller comes to engage with the workpiece in arectilinear motion, a cylindrical bolt is expediently inserted in a borein the slide, on the one hand, and in an oblong hole in the lever, onthe other. The minimum working aperture for the tool, which isdetermined by the radial position of the bending roller in the case of apressing member that is moved relatively in the direction of the slide,can be fixed for example by varying the diameter of the rollerassociated with the lever which rolls on the pressing member and it isnot absolutely necessary for the lever to be adjustable relative to theslide. The shaping of the bearing point by means of the inexpensivecylindrical bolt, which is fixed in the slide on the one hand andinserted in the oblong hole of the lever on the other hand, meets therequirements.

In order to achieve a defined deflection of the respective direction ofmovement reliably and reproducibly, the lever is preferably pivotablymounted on a carrier member. The carrier member is fixedly positionedrelative to the slide in the axial direction and movable relative to thepressing member.

Preferably the pressing member is resiliently mounted in the axialdirection. When the bending roller is in its radial end position, inwhich it describes the minimum working aperture for the tool and thefinal dimensions of the workpiece have been achieved, the pressingmember moves counter to the spring force acting upon it, in order toprevent further advancing of the bending roller with resultantdestruction of the workpiece. However with the spring-loaded overloadprevention device it is also possible to generate the pressure needed toensure the deformation and any tolerances in the workpiece can beequalised. The resilience associated with the pressing member may beeffective both with an undersized workpiece and with an oversized oneand will always clamp the bending roller against the workpiece. Toprovide the spring force, a central compression spring may be arrangedor a plurality of compression springs uniformly distributed over thecircumference of the pressing member may be provided.

According to one feature, at least one shaping roller for producing acrimp is rotatably mounted on an axis of the slide adjacent to thebending roller. Expediently, the slide is slidably mounted on two guidebolts spaced from each other in a guide portion, the guide portion beingconnected to the carrier member. Obviously, the slide may consist of aslidable material or have sliding bushes which run on the guide bolts,thereby largely ruling out any jamming.

For reproducibly adjusting the height of the shaping tool by simplemeans, a cam roller advantageously cooperates with a cam control for theaxial movement of the shaping tool. The travel speeds and distances maybe decided by means of the control cam of the cam control in knownmanner. The cam roller may be mounted in particular on a housing of theshaping tool.

Expediently, three radially adjustable slides each having one lever arearranged in a star shape with one another. The workpiece can be shapedrelatively uniformly with the equidistantly distributed bending andshaping rollers and a high surface quality can be achieved at a highshaping speed while adhering to relatively narrow tolerances of form anddimensions.

A retaining device fixes the workpiece, which consists of an aluminiumcartridge and a plastic container, coaxially with respect to alongitudinal axis along which the shaping tool travels vertically. Theretaining device may be part of a conveying and/or packaging apparatus,for example in the form of a rotary plate machine or a conveyor belt.

The shaping tool described above is used for profiling a neck region ofan inhaler cartridge which consists of an exterior aluminium cartridgeand a plastic container placed therein which holds an active substanceformulation. The plastic container can be produced by the co-extrusionmethod and may comprise a rigid outer container and a flexible innerpouch disposed therein. In the course of manufacture, the plasticcontainer is filled with the pharmaceutical active substance formulationand sealed.

The inhaler cartridge manufactured with the shaping tool is used as astorage container in a nebuliser for dispensing a specified amount of afluid, particularly one that contains a medicament, as an aerosolthrough a nozzle from a pressurised store, wherein a mechanical pressuregenerator acts upon the measured out fluid in the pressurised storewhich is to be released in one go for nebulisation. A known nebuliser ismarketed by Boehringer Ingelheim KG under the brand name “Respimat” inthe form of an inhaler and is shown in WO 91/14468 A1 and in WO 97/12687A1.

It will be understood that the features mentioned above and to beexplained hereinafter may be used not only in the particular combinationspecified but also in other combinations. The scope of the invention isdefined only by the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention is hereinafter explained in more detail by means of twoembodiments by way of example, by reference to the attached drawings,wherein:

FIG. 1 is a front view of a shaping tool according to the invention.

FIG. 2 is a sectional view of the shaping tool according to FIG. 1 onthe line II-II.

FIG. 3 is a schematic partial representation of the shaping toolaccording to FIG. 1.

FIG. 4 is a partial representation of the shaping tool according to FIG.1 in section.

FIG. 5 is another representation of the shaping tool according to FIG. 4in section.

FIG. 6 is a representation of a nebuliser with an inhaler cartridgeproduced using the shaping tool according to FIG. 1, in section.

DETAILED DESCRIPTION OF THE INVENTION

The shaping tool comprises a rod 2 mounted in a hollow shaft 1 andconnected to a rotary drive (not shown). An axial up and down movementof the shaping tool is controlled by means of a radially mounted camroller on the tool side, which cooperates with a cam control. In ahousing (not shown) are various mounting, coupling and spring elements.

Underneath the housing is secured a pressing member 5 with a conicalregion 6 and underneath the pressing member 5 are a carrier member 7 anda guide portion 8, while pivotably mounted in the carrier member 7 arethree levers 9 which comprise, at one end, rollers 10 cooperating withthe pressing member 5, while the opposite ends from the rollers 10 actupon slides 11 mounted in the guide portion 8. Each of the slides 11 hasa bending roller 13 and a shaping roller 14 on a spindle 12. For guidingthe slide lithe guide portion 8 is fitted with guide bolts 22 alignedparallel and at a spacing from one another and the slides 11 areprovided with sliding bushes 23 which run on the guide bolts 22.Obviously, the guide bolts 22 are aligned such that the slides 11 movein the radial direction.

By means of the pivotable levers 9, the bending rollers 13 can be movedout of a position that defines a maximum working aperture for the toolinto a position that defines a minimum working aperture for the tool.Specifically, in a downward movement of the rotating shaping tool asindicated by the arrow 16, a depressor 15 first of all presses directlyon a workpiece 17, namely an inhaler cartridge 36. As the downwardmovement continues, the levers 9 are pivoted in the direction of thearrow 18 as a result of the activity of the conical region 6 of thepressing member 5 and the pivoting movement of the lever 9 is convertedinto a radial advancing movement of the slide 11 in the direction of thearrow 19, in order to move the bending roller 13 and the shaping roller14 into their end position in which they describe the minimum workingaperture for the tool. When the shaping tool is moved axially upwards,the levers 9 are pivoted by means of radially acting compression springssupported on an intermediate ring 20 on the one hand and in a blind bore26 of the associated lever 9 on the other hand, so that the bendingroller 13 and the shaping roller 14 are moved into a position in whichthey describe the maximum working aperture for the tool.

In order to avoid damage to the workpiece 17, which consists of analuminium cartridge 21 with a plastic container 38 inserted therein, andprovide equalisation of tolerances for different workpiece dimensions,the pressing member 5 is mounted to be axially movable, through beingspring-loaded by compression springs 31, a plurality of compressionsprings 31 being uniformly distributed. During axial movement of thepressing member 5 in the direction of the workpiece 17, the roller 10 ofthe lever 9 travels over the conical region 6 of the pressing member 5and the one-piece lever 9 swivels counter to the action of the radiallyacting restoring spring about the swivel joint 27, which comprises a pin28 engaging in the carrier member 7. At the same time a cylindrical bolt32 inserted in the slide 11 slides in an oblong hole 24 in the lever 9,as a result of which the slide 11 is moved radially towards theworkpiece 17. Once the bending roller 13 and the shaping roller 14 havereached their end positions, the pressing member 5 is moved counter tothe action of the compression springs 31 relative to the workpiece 17,without the slide 11 undergoing any further radial advancing in thedirection of the workpiece 17.

With the bending rollers 13 a radius 33 is formed in the circumferentialedge region of the workpiece 17, the free edge of the aluminiumcartridge 21 being shaped by the fact that it rests on the free end faceof the plastic container. The shaping rollers 14 serve essentially toshape two encircling groove-like crimps 34 in a drawn neck region 35 ofthe workpiece 17.

The inhaler cartridge 36 is used in a nebuliser 37 which is used tonebulise a fluid 39, particularly a highly potent medicament, and is inthe form of a portable inhaler that operates without propellant gas.When the fluid 2, preferably a liquid, is nebulised, an aerosol isformed which can be breathed in by a user (not shown).

The nebuliser 37 comprises the inhaler cartridge 36 holding the fluid39, which can be inserted in the opened nebuliser 37 from below. Inorder to nebulise a predetermined adjustable amount of the fluid 39, thenebuliser 37 comprises a pressure generator 41 surrounding a piston,with a holder 42 for the inhaler cartridge 36, a drive spring 43 with amanually operated release button 44 for releasing the pressure, aconveying tube 40 with a non-return valve 45 inserted, a pressurechamber 46 and a nozzle 47, with which a mouthpiece 48 is associated.

As the drive spring 43 is axially tensioned by rotation of a lowerhousing part 49 with an inner part 50 releasably attached thereto,relative to an upper housing part 51 formed on the mouthpiece 48, theholder 42 is moved downwards with the inhaler cartridge 36 and theconveying tube 40 and fluid 39 is sucked out of the inhaler cartridge 36through the non-return valve 45 into the pressure chamber 46 associatedwith the piston of the pressure generator 41. During the subsequentabrupt relaxation of the drive spring 43 by actuating the release button44, the fluid 39 in the pressure chamber 46 is pressurised by the drivespring 43 moving the conveying tube 40 upwards and is expelled throughthe nozzle 47, whereupon nebulisation takes place. The nebulisationtakes place for example in particles in the μm range, preferably inparticles around 20 in size, which form a mist or jet of aerosol. A useris able to inhale the aerosol, while supply air can be sucked in throughsupply air openings 52 in the mouthpiece 48.

LIST OF REFERENCE NUMERALS

-   1. hollow shaft-   2. rod-   5. pressing member-   6. conical region-   7. carrier member-   8. guide portion-   9. lever-   10. roller-   11. slide-   12. spindle-   13. bending roller-   14. shaping roller-   15. depressor-   16. arrow-   17. workpiece-   18. arrow-   19. arrow-   20. intermediate ring-   21. aluminium cartridge-   22. guide bolt-   23. sliding bush-   24. oblong hole-   26. blind bore-   27. swivel joint-   28. pin-   31. compression spring-   32. cylindrical bolt-   33. radius-   34. crimp-   35. neck region-   36. inhaler cartridge-   37. nebuliser-   38. plastic container-   39. fluid-   40. conveying tube-   41. pressure generator-   42. holder-   43. drive spring-   44. release button-   45. non-return valve-   46. pressure chamber-   47. nozzle-   48. mouthpiece-   49. lower housing part-   50. inner part-   51. upper housing part-   52. supply air openings

1. A shaping tool comprising a rotatable base member having at least oneprofiled bending roller (13) which is mounted on a circular track and isrotatable about a rotation axis, characterised in that the bendingroller (13) arranged on a radially movable slide (11) is movable from aposition that defines a maximum working aperture for the tool, by meansof a spring-loaded lever (9) with an axial configuration, into aposition that defines a minimum working aperture for the tool. 2.Shaping tool according to claim 1, characterised in that in the center,an axially acting depressor (15) for the clamped workpiece (17) isprovided and a pressing member (5) that is conical at least in parts isaxially movable under spring loading relative to the depressor (15),while the pressing member (5) cooperates with one end of the lever (9)in order to move the bending roller (13) into the minimum workingaperture for the tool.
 3. Shaping tool according to claim 1,characterised in that the lever (9) is provided, at its end facing thepressing member (5), with a roller (10) that rolls on the pressingmember (5) and at its opposite end it is pivotably connected to theslide (11).
 4. Shaping tool according to claim 3, characterised in thata cylindrical bolt (32) is inserted in a bore in the slide (11), on theone hand, and in an oblong hole (24) in the lever (9), on the other. 5.Shaping tool according to claim 1, characterised in that the lever (9)is pivotably mounted on a carrier member (7).
 6. Shaping tool accordingto claim 1, characterised in that the pressing member (5) is resilientlymounted in the axial direction.
 7. Shaping tool according to claim 1,characterised in that at least one shaping roller (14) for producing acrimp (34) is rotatably mounted on a spindle (12) of the slide (11)adjacent to the bending roller (13).
 8. Shaping tool according to claim1, characterised in that the slide (11) is slidably mounted on twospaced-apart guide bolts (22) in a guide portion (8), the guide portion(8) being connected to the carrier member (7).
 9. Shaping tool accordingto claim 1, characterised in that a cam roller cooperates with a camcontrol for the axial movement of the shaping tool.
 10. Shaping toolaccording to claim 1, characterised in that three radially adjustableslides (11) each having one lever (9) are arranged in a star shape withone another.
 11. Shaping tool according to claim 1, characterised inthat a retaining device fixes the workpiece (17), which consists of analuminium cartridge (21) and a plastic container, coaxially with respectto a longitudinal axis along which the shaping tool travels vertically.12. Use of a shaping tool according to claim 1 for profiling a neckregion (35) of an inhaler cartridge (36), which consists of an externalaluminium cartridge (21) and a plastic container (38) inserted thereinholding an active substance formulation.
 13. An inhaler cartridge (36)having a neck region (35), which consists of an external aluminiumcartridge (21) and a plastic container (38) inserted therein holding anactive substance formulation, wherein the neck region (35) of theinhaler cartridge (36) is profiled using the shaping tool according toclaim
 1. 14. The inhaler cartridge according to claim 13, characterisedin that it is used as a storage container in a nebuliser (37) fordispensing a specified amount of a fluid (39), particularly one thatcontains a medicament, as an aerosol through a nozzle (47) from apressurised store, wherein a mechanical pressure generator (41) actsupon the measured out fluid (39) in the pressurised store which is to bereleased in one go for nebulisation
 15. The inhaler cartridge accordingto claim 14, characterised in that the pressure generator (41)surrounding a piston comprises a holder (42) for the inhaler cartridge(36) in its neck region (35) produced with the shaping tool, and a drivespring (43) associated with the pressure generator (41) having a releasebutton (44) and a conveying tube (40) are provided, wherein axialtensioning of the drive spring (43) moves the holder (42) with theinhaler cartridge (36) and the conveying tube in an opposite directionto the nozzle (47) and sucks fluid (39) out of the inhaler cartridge(36) into the pressure chamber (46).